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***PKTX..ProtoKinetix’ AAGP® Signs a Material Transfer Agreement with a Reputed International Biotech Company
Marietta, Ohio, June 13, 2018

ProtoKinetix, Incorporated (www.protokinetix.com) (the "Company" or "ProtoKinetix") (OTCQB:PKTX) is pleased to announce that ithas executed a Material Transfer Agreement (MTA) with a reputed biotechnology company having a number of worldwide offices on four continents.

Under the MTA, ProtoKinetix and this company are working together to test the effects AAGP®have on three projects:
Cryopreservation of Primary Mammalian Tissue Cells
Enhancing the Viability of Primary Mammalian Cells
Cell Lines Under Stressed Culture Conditions
Before testing a drug in human patients, researchers use primary cells from different human donors to verify that the same effects are observed. Except for the enzymatic and/or physical dissociation required for extracting the cells from their tissue of origin, primary cells are not altered in any way. Primary Cell lines are hardy, chiefly because they have to last a long time in culture and be capable of surviving multiple rounds of cryopreservation and thawing.

Mammalian cell culture is at the core of bio manufacturing therapeutic proteins and viral vaccines. Cells isolated from animal tissues can be expanded in culture for use as a research tool for the production of virus vaccines and various therapeutic proteins, and to generate functional cells or tissue analogues for regenerative medicine. In the past quarter century, cells derived from animals, especially mammals, have become a major vehicle for producing biologics, a class of medications that includes vaccines and various proteins used in treating cancer, genetic diseases, and other ailments.

Mammalian cells can be made to produce vaccines through viral infection and therapeutic proteins through genetic engineering. Many of these medicines are necessary for patients who either lack the normal form of a protein or cannot produce it in sufficient quantity. Other therapeutic proteins include antibodies and specific binding proteins that neutralize disease-causing molecules within the body. Human cells, in particular, are poised to enable opportunities in cell-based therapy and regenerative medicine. The technology that exists now can derive stem cells from many sources and guide them to become specific cell types for clinical applications.

Preliminary results of the testing program are scheduled to be presented to ProtoKinetix by mid- summer. Should these results be successful, under the MTA, this company has the right to negotiate a licensing agreement for each application initiating the global commercialization of AAGP®.

Based on projections from Grand View Research, Inc., the global cell line development market size is expected to reach $3.96 billion by 2019 and is anticipated to grow at a compound annual growth rate (CAGR) of 12.9% over the forecast period. Growing biopharmaceutical industry is anticipated to drive the demand for cell line development procedures.

President and Chief Executive Officer Clarence E. Smith commented, “We are delighted to be collaborating with this reputed, international biotechnology companywith facilities worldwide. If testing proves to be successful, this may give ProtoKinetix the first opportunity to license out AAGP®”.

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