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Health care bill getting disected......
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[QUOTE]Originally posted by glassman: [QB] :b: are these people even really sick? [b]Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why. By Steve Silberman 08.24.09 From 2001 to 2006, the percentage of new products cut from development after Phase II clinical trials, when drugs are first tested against placebo, rose by 20 percent. The failure rate in more extensive Phase III trials increased by 11 percent, mainly due to surprisingly poor showings against placebo. Despite historic levels of industry investment in R&D, the US Food and Drug Administration approved only 19 first-of-their-kind remedies in 2007—the fewest since 1983—and just 24 in 2008. Half of all drugs that fail in late-stage trials drop out of the pipeline due to their inability to beat sugar pills. The upshot is fewer new medicines available to ailing patients and more financial woes for the beleaguered pharmaceutical industry. Last November, a new type of gene therapy for Parkinson's disease, championed by the Michael J. Fox Foundation, was abruptly withdrawn from Phase II trials after unexpectedly tanking against placebo. A stem-cell startup called Osiris Therapeutics got a drubbing on Wall Street in March, when it suspended trials of its pill for Crohn's disease, an intestinal ailment, citing an "unusually high" response to placebo. Two days later, Eli Lilly broke off testing of a much-touted new drug for schizophrenia when volunteers showed double the expected level of placebo response. Some products that have been on the market for decades, like Prozac, are faltering in more recent follow-up tests. In many cases, these are the compounds that, in the late '90s, made Big Pharma more profitable than Big Oil. But if these same drugs were vetted now, the FDA might not approve some of them. Two comprehensive analyses of antidepressant trials have uncovered a dramatic increase in placebo response since the 1980s. One estimated that the so-called effect size (a measure of statistical significance) in placebo groups had nearly doubled over that time.[/b] [URL=http://www.wired.com/medtech/drugs/magazine/17-09/ff_placebo_effect?currentPage=all]http://www.wired.com/medtech/drugs/magazine/17-09/ff_placebo_effect?currentPage= all[/URL] who cares if it works better than a sugar pill as long as it's profitable? :rolleyes: this may seem like a "disconnect" but we need to ban advertising of all prescription drugs immediately, because of the power of suggestion. besides i'm tried of hearing about side effects of prostate pills during the news... we could prolly cut health care costs alot by simply presrcibing sugar pills.. ;) [b]Why are inert pills suddenly overwhelming promising new drugs and established medicines alike? The reasons are only just beginning to be understood. A network of independent researchers is doggedly uncovering the inner workings—and potential therapeutic applications—of the placebo effect.[/b] how long before the drug co's patent placebos too? :c: [/QB][/QUOTE]
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