DNAPRINT GENOMICS NEW (U-DNAG) - News Release DNAPrint Pharmaceuticals / Harvard Study Shows PT-401 to Be Three Times More Potent Than Conventional EPOs in Treating Anemia
2006-12-08 07:00 ET - News Release
SARASOTA, FL -- (MARKET WIRE) -- 12/08/06
DNAPrint Genomics, Inc. (OTCBB: DNAG) today announced the results of preclinical studies conducted by the Company and Harvard Medical School on the Company's proprietary PT-401 protein. The studies demonstrate that PT-401 is three times more effective than conventional EPO treatments, and conclude that PT-401 has "biological activities superior to those of EPO monomer, suggesting important therapeutic advantages."
The results of the study will be formally presented by Drs. Jee-Yeong Jeong and Arthur J. Sytkowski on Dec. 9, 2006, at the American Society of Hematology 48th Annual Meeting and Exposition in Orlando, Fla. Dr. Sytkowski is the Director of the Laboratory for Cell and Molecular Biology at Beth Israel Deaconess Medical Center (BIDMC), an affiliate of Harvard Medical School.
The study's purpose was to determine whether it was possible to develop a more effective erythropoiesis stimulating agent (ESA) than human erythropoietin (EPO, epoetin), which is widely used in the treatment of certain forms of anemia but which has a relatively short in vivo half-life, resulting in considerably high and frequent doses in order to maintain therapeutic effectiveness. The study, conducted over a seven day period using laboratory mice, showed that the "super EPO" that forms the basis for PT-401, and which comprises EPO-dimer and EPO-trimer fusion proteins that were comprised of "head-to-tail" repeats, is up to three times more effective than conventional EPO treatments, exhibiting enhanced biological properties in vitro and in vivo.
"Dr. Sytkowski is one of the foremost scientists in the field of therapeutic protein research, particularly Erythropoietin," stated DNAPrint Chairman and Chief Medical Officer Hector J. Gomez, M.D., Ph.D. "We are proud that our affiliation with Dr. Sytkowski and Beth Israel Deaconess Medical Center has produced this research, which shows the promise of PT-401 in treating chronic anemia due to renal failure, cancer, or other causes."
"This study is an important step in the advancement of PT-401 as a potential competitor in the EPO market, which currently exceeds $10 billion and is rapidly growing," stated DNAPrint Genomics President and Chief Executive Officer Richard J. Gabriel. "This study is just one step, however, and we look forward to continuing our collaboration with Dr. Sytkowski as this project advances."
PT-401 is a "Super EPO," a more powerful erythropoiesis stimulating agent than Erythropoietin, a well-known drug used for the treatment of anemia. Previously, DNAPrint Pharmaceuticals, the Company's wholly owned subsidiary, announced three successful milestones related to PT-401: the use of CHO cell lines, the use of SDS-PAGE, a well-established separation technique for the testing of cell lines, and a specially developed isoelectric focusing (IEF) method. The initial research has been conducted in conjunction with Dr. Sytkowski.
In addition to Dr. Sytkowski, research was carried out with Drs. Jee-Yeong Jeong, Changmin Chen and Kerry L. Davis of the Laboratory for Cell and Molecular Biology, Division of Hematology and Oncology at the Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School.
The study was conducted in conjunction with the UCLA Olympic Analytical Laboratory in the Department of Molecular and Medical Pharmacology at the University of California at Los Angeles and included Drs. Andreas Breidbach and Don H. Caitin.
The study and its results are illustrated in a multi-color poster that Dr. Sytkowski will distribute as part of the presentation.
About Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School, and ranks third in National Institutes of Health funding among independent hospitals nationwide. BIDMC is clinically affiliated with the Joslin Diabetes Center and is a research partner of Dana-Farber/Harvard Cancer Center. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.harvard.edu.
About DNAPrint Genomics, Inc.
DNAPrint Genomics, Inc. (www.dnaprint.com) is a developer of genomics-based products and services in two primary markets: biomedical and forensics. DNAPrint Pharmaceuticals, Inc., a wholly owned subsidiary, develops diagnostic tests and theranostic products (drug/test combinations) using the Company's proprietary ancestry-informed genetic marker studies combined with proprietary computational modeling technology. Computational Biology and Pharmacogenomics services are also offered externally to biopharmaceutical companies. The Company's first theranostic product is PT-401, a "Super EPO" (erythropoietin) dimer protein drug for treatment of anemia in renal dialysis patients (with end stage renal disease). Preclinical and clinical development of all the Company's drug candidates will benefit from simulated pre-trials to design actual trials better and are targeted to patients with genetic profiles indicating their propensity to have the best clinical responses. DNAPrint is proud of its continued dedication to developing and supplying new technological advances in law enforcement and consumer ancestry heritage interests. Please refer to www.dnaprint.com for information on law enforcement and consumer applications which include DNAWITNESS(TM), RETINOME(TM), ANCESTRYbyDNA(TM) and EURO-DNA(TM). DNAWitness-Y and DNAWitness-Mito are two tests offered by the Company. The results from these tests may be used as identification tools when a DNA sample is deteriorated or compromised or other DNA testing fails to yield acceptable results.
Forward-Looking Statements
All statements in this press release that are not historical are forward-looking statements. Such statements are subject to risks and uncertainties that could cause actual results to differ materially from those projected, including, but not limited to, uncertainties relating to technologies, product development, manufacturing, market acceptance, cost and pricing of DNAPrint's products, dependence on collaborations and partners, regulatory approvals, competition, intellectual property of others, and patent protection and litigation. DNAPrint Genomics, Inc. expressly disclaims any obligation or undertaking, except as may be required by applicable law or regulation to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in DNAPrint's expectations with regard thereto or any change in events, conditions, or circumstances on which any such statements are based.
Company Contact: Richard Gabriel CEO and President 941 366-3400
Ron Stabiner The Wall Street Group, Inc. 212-888-4848
Posted by Prdponce on :
moving
Posted by jas2mel on :
moving well on good pr
Posted by cmsrem on :
Interesting pps was 10x as much 3 weeks ago
Posted by Prdponce on :
.0084
Posted by Prdponce on :
has a lot of shares but that PR could send it to .01 IMO
Posted by jas2mel on :
nice volume
Posted by cmsrem on :
380 million?
Posted by IMAKEMONEY on :
I LIKE IT AND IM IN IT!!! Posted by Prdponce on :
quick dip
Posted by IMAKEMONEY on :
LOOKING STACKED AND READY FOR A RUN!JMO
Posted by Prdponce on :
.0083 x .0084
Posted by IMAKEMONEY on :
FILL THAT GAP!! Posted by djg7 on :
Damn, got partial at .0082 and can't get filled at .0084.
Posted by IMAKEMONEY on :
HERE COME THE .0090s Posted by Zsartell on :
I finally got filled at .0084 been trying all morning. Lets see this skyrocket!
Posted by djg7 on :
Can't get filled.
Posted by a surfer on :
in at 86..
Hello IMAKE..
Posted by Prdponce on :
i thing MMS are going to move quickly with 5 K trades on those .009's
Posted by IMAKEMONEY on :
WHATS UP SURFER? HOWZIT GOING? .0088
Posted by IMAKEMONEY on :
BOOM .0090s
Posted by Phoenix on :
quote:Originally posted by cmsrem: Interesting pps was 10x as much 3 weeks ago
3 weeks ago looked like a fat-finger buy..
Posted by Prdponce on :
quote:Originally posted by Prdponce: i thing MMS are going to move quickly with 5 K trades on those .009's
WOW A GENIUS << LOL
Posted by IMAKEMONEY on :
CANT WAIT TO SEE THIS MOVING AFTER IT GOS OVER .01 CRAZY!! UPSIDE,IMO
Posted by IMAKEMONEY on :
PPS .0094- NICE CALL Prdponce
Posted by djg7 on :
Ponce, another good find as usual.
Posted by Prdponce on :
Filling the 009's now
LPTI >>> Watch for volume it could move nice
Posted by IMAKEMONEY on :
HOD .0095 AND HEADING BACK UP!! PPS .0094
Posted by IMAKEMONEY on :
NEW HOD .0097!
Posted by djg7 on :
Uptick .0096 x .0097.
Posted by djg7 on :
Man, you're fast Imake.
Posted by IMAKEMONEY on :
NITE IS DEEP IN THE .01s ARCA IS THE WALL AT .0148
Posted by jas2mel on :
breaking .01 soon
Posted by Zsartell on :
Do you smell that? I do....
Posted by Prdponce on :
.01 MONSTAAAAAAAAAAAAAAAA
Posted by jas2mel on :
there it is
Posted by IMAKEMONEY on :
SEATBELTS ON!! NEW HOD .0105
Posted by djg7 on :
1.6 MIL trade at .01.
Posted by IMAKEMONEY on :
HERE COMES .0110 Posted by jas2mel on :
how far is this going to go WOW
Posted by Zsartell on :
To the MOON jas2mel!
Posted by a surfer on :
holy crap gone for a few min and boom..
Good IMAKE and you..
I have had a great week!
Posted by IMAKEMONEY on :
ARCA DROPED TO .0140 NICE WE GO HIGHER! SORRY I POSTED THAT ALREADY. GOOD SURFER, SAME OLD THING FOR ME JUST MAKING MONEY.LOL
Posted by jordanreed on :
take profits
Posted by jas2mel on :
too early jordanreed
Posted by jordanreed on :
never too early
Posted by IMAKEMONEY on :
THIS PUPS HAS BEEN TO .08 ILL TAKE .04 -LOL
Posted by IMAKEMONEY on :
ALWAYS SMART TO TAKE PROFIT, A WIN IS A WIN. BUT IM STLL IN FOR THE BIG WIN. Posted by Zsartell on :
Crap, my ticker stopped, what do we have now..
Posted by djg7 on :
Dip .01*3 x .0101*1
Posted by Zsartell on :
Where do you think we're headed guys?
Thanks djg7!
Posted by IMAKEMONEY on :
NICE DIP AND GAP FILL, THEN BOOM TIME AGIAN!
Posted by jordanreed on :
not in this...wish i was..just wanted to say that it looks as if it may be done till maybe after lunch??..nice run this morning,,now is usually the retrace time for these spikers..
ALWAYS take profits when they show themselves...
Posted by djg7 on :
Gaps have to fill on the way up.
Posted by IMAKEMONEY on :
UBSS AND NITE HAVE BOTH MOVED BACK! LET IT GO BOYZ! Posted by djg7 on :
Big spread .0101 x .0107. Let's get that narrowed upward.
Posted by IMAKEMONEY on :
PRINTING .0108s
Posted by jas2mel on :
looks like it is
Posted by IMAKEMONEY on :
NEXT LEG UP HERE WE COME!
Posted by IMAKEMONEY on :
LETS SLAP THAT HOD!!LOL
Posted by Zsartell on :
Keep on chugging along!
I think we could hit .02 today.
Well, it doesn't hurt to be optimistic....or does it?
Posted by IMAKEMONEY on :
IT COULD.LOL Posted by djg7 on :
1,000 share trade. MMs need shares.
Posted by IMAKEMONEY on :
WHAT I SEE IS NITE UBSS AND ARCA ALL WONT SELL, THATS WHAT IM WATCHING, BUT THEY DO WANT TO BUY!
Posted by invester on :
I'm in at .01.
Posted by IMAKEMONEY on :
OK NOW UBSS IS ON WILL HE STAY!
Posted by djg7 on :
Invester was that you that made that 1.6 MIL share trade at .01?
Posted by invester on :
I never kiss and tell. LoL.
Posted by IMAKEMONEY on :
NOPE THEY WONT WHOLED THERE GROUND, I SAY ITS A SHAKE OUT! JMO
Posted by djg7 on :
Invester, LMAO.
Posted by invester on :
Posted by Zsartell on :
She's dipping...
Posted by IMAKEMONEY on :
BUT WILL SHE COME RUNNING BACK? Posted by Zsartell on :
Ah man, we're screwed. They never come back to me. I've doomed us all....;-)
Posted by djg7 on :
Think positive Z.
Posted by IMAKEMONEY on :
LMAO, STACKNG BACK UP NOW. Posted by djg7 on :
Bid keeps upticking. Maybe primed for another run.
Posted by invester on :
You got shook Biatch!!!!!!
Posted by djg7 on :
WTF, trades going through below the bid!
Posted by Zsartell on :
I am djg7. I'm sticking around to see what happens for sure...
This ones going all the way and I smell the green on the other side!!
Dips over...
Posted by djg7 on :
That's cool Z.
Posted by Prdponce on :
I am waiting for an EOD run or .015,,, what ever come first, LOL
Posted by djg7 on :
Lunch time lull. Should pick up this afternoon.
Posted by IMAKEMONEY on :
IM BACK Prdponce GREAT PICK AND LOOKS TO BE GETTING READY TO RUN AGIAN! ALSO LOOKING FOR .015s Posted by Zsartell on :
Ouch... .0096 Lets see it pick back up for a hard core EOD run...
Posted by IMAKEMONEY on :
LOOK WE WERE JUST AT 52 WEEK LOW, GREAT NEWS SHOULD GO UP!
Posted by djg7 on :
It's dropping. It may be day traders taking profit.
.0091 x .0092.
Posted by Zsartell on :
I'm still holding to EOD. Get those profit takers out of the way and then we can run again...
Posted by djg7 on :
strong bid support at .009.
.009*7 x .0091*1
Posted by IMAKEMONEY on :
LOOKING GOOD!!!!
Posted by IMAKEMONEY on :
ARCA IS READY TO BUY IT ALL IF IT FALLS TO THE .0090 BUT WONT SELL TILL .0148 HMM
Posted by djg7 on :
Just got back. Bid support still heavy at .009. Hope this loads up for an EOD run.
Posted by Zsartell on :
.0094!, come on baby lets see some more action.... ARCA is way down there now...
Posted by djg7 on :
500 share trade at .0093 may indicate that they might let this run a little bit.
Posted by djg7 on :
OLMP has a tight grip on this at .0095. I wonder where he came from.
Posted by djg7 on :
ARCA move heavy on bid at .0095. It's going north again.
Posted by IMAKEMONEY on :
EOD RUNNER!!!!!!!!!
Posted by IMAKEMONEY on :
WELL SAID!!!LOL.invester Member
posted December 08, 2006 11:24 AM -------------------------------------------------------------------------------- You got shook Biatch!!!!!! -------------------------------------------------------------------------------- Posts: 2468 | From: houston | Registered: Mar 2006 | IP: Logged |
Posted by djg7 on :
.0099 getting hit hard. Looks like it's ready to crack.
Posted by djg7 on :
ARCA keeps following up on the bid. Go baby Go!
Posted by IMAKEMONEY on :
ARCA NOW WANTS IT AT .01 WE SHOULD FLY!! IMO
Posted by jordanreed on :
i predict it will make it almost back to the hod...
but not over...
Posted by IMAKEMONEY on :
BET IT GOS OVER, jordanreed HOD .0109
Posted by djg7 on :
I'll take that jordanreed.
Posted by jordanreed on :
i aint a bettin..
lol
Posted by djg7 on :
I like what IMAKE is thinking better.
Posted by IMAKEMONEY on :
ITS THE LAST 20 MINS THAT WILL TELL ALL,IMO EOD .0137 AND IM HOLDEN. Posted by IMAKEMONEY on :
GET READY!!! Posted by djg7 on :
Good bid support at .01. Let's go.
Posted by IMAKEMONEY on :
LETS GOOOOOOOOOOOOOOOOOOOO$$
Posted by jordanreed on :
hope you all took my advise earlier and took profits...
Posted by djg7 on :
They're bringing this back to ARCA at .0093.
Posted by IMAKEMONEY on :
HELL NO,LOL jordanreed Member
posted December 08, 2006 03:52 PM -------------------------------------------------------------------------------- hope you all took my advise earlier and took profits...
-------------------- jordan
-------------------------------------------------------------------------------- Posts: 2942 | From: st paul,mn | Registered: Feb 2004 | IP: Logged |
Posted by djg7 on :
Going north EOD. YES!
Posted by IMAKEMONEY on :
MONDAYS GAPPER!!
Posted by djg7 on :
OLMP is being an a$$hole today.
Posted by IMAKEMONEY on :
YOU WON ON THAT, BUT UP 41% TODAY, FLIPPED IT THREE TIMES, AND GONNA GO HIGHER ON MONDAYS PR,JMO jordanreed Member
posted December 08, 2006 02:43 PM -------------------------------------------------------------------------------- i predict it will make it almost back to the hod...
but not over...
-------------------- jordan
-------------------------------------------------------------------------------- Posts: 2942 | From: st paul,mn | Registered: Feb 2004 | IP: Logged |
Posted by jordanreed on :
great work today imake
Posted by jordanreed on :
mondays pr???did they say that?
Posted by IMAKEMONEY on :
![[Big Grin]](biggrin.gif)
![[Smile]](smile.gif)
![[Wink]](wink.gif)
![[Razz]](tongue.gif)
![[Eek!]](eek.gif)