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Author Topic: XKEM
amswap
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The thread just disappeared, so I guess we need to start a new one!
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Dustoff 1
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My last post wasn't that much trouble, did I blow up something? LOL
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jordanreed
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best laugh i've had all day!! [Smile]

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jordan

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amswap
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I guess you did Dust. Not sure what happened. I went to refresh and it was gone. What did you say that was so destructive?
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10of13
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What the heck? LOl Dustoff what did you do?

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#1 Rule: Protect your capital! #2 Rule: Never fall for the BS on the boards!

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Purl Gurl
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Take that as a hint unpleasant behavior is
not welcomed here at Allstocks.

You have a second chance. Do not abuse it.

Purl Gurl

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jordanreed
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ok... back to the soap...

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jordan

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amswap
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If unpleasant behavior is not allowed, why haven't they thrown you off purl?
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Dustoff 1
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Well, maybe I better not, don't want to blow up Allstocks...Geez, me 'puters is Pow-ur-ful!
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Purl Gurl
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Amswap, I strongly urge you to no longer engage
in insulting other people. That behavior is
not welcomed here at Allstocks.

Purl Gurl

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amswap
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Kinda glad they did take it off. The other one was getting too long anyway.
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amswap
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quote:
Originally posted by Purl Gurl:
Amswap, I strongly urge you to no longer engage
in insulting other people. That behavior is
not welcomed here at Allstocks.

Purl Gurl

You really are a joke. You are the one that belittles and insults people. How dare you tell me I did something wrong. Who have I insulted?
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10of13
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amswap and Purl...kiss and make up already...let's start this thread being nice...

Don't do it...I know what you're thinking.. [Big Grin]

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#1 Rule: Protect your capital! #2 Rule: Never fall for the BS on the boards!

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Purl Gurl
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I warned you, Amswap.

Purl Gurl

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Vance
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amswap get use to it. Purl is great at turning things around and crying wolf. Better get use to her though, becuase once she shows up to on a thread it's hard to get her off... She probably turned you in already, hahaha what a joke...GLTY

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Success is having the time and money to enjoy all of life's wonders...

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amswap
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If she can engage in conversation without trashing and making others contribution here seem like it is a waste of time, I will lay off. She is the one that continually tries to make peopple think she is the only one capable of thinking on here. It got old quick. If she will stop trashing people for what they say and questioning everything and holding them accountable when they say something that may not be 100% accurate, then she too needs to do the same thing.
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amswap
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quote:
Originally posted by Purl Gurl:
I warned you, Amswap.

Purl Gurl

Warning accepted. Now how about answering my question? I'll ask again:

WHO HAVE I INSULTED?????????????????????

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10of13
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quote:
Originally posted by amswap:
quote:
Originally posted by Purl Gurl:
I warned you, Amswap.

Purl Gurl

Warning accepted. Now how about answering my question? I'll ask again:

WHO HAVE I INSULTED?????????????????????

AMSSSS!!!! Please ...Just ignore it...

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#1 Rule: Protect your capital! #2 Rule: Never fall for the BS on the boards!

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Dustoff 1
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Ok, I'll try again, this is basicly what I asked on the last post....

Want something to discuss?
Gates Foundation...

Told ya, I can make trouble...

In a more serious light? I want to see the opinions of others on the subject..

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10of13
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anyone know how we can get that other thread back...just for the DD alone...???

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#1 Rule: Protect your capital! #2 Rule: Never fall for the BS on the boards!

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amswap
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10, if you click on some of the names of people who posted in that thread and click on recent posts, it was comeing up that way. Not sure it still is.

And sorry about above. I know she isn't capable of answering a question. Not sure why I bothered asking.

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T e x
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quote:
Originally posted by 10of13:
anyone know how we can get that other thread back...just for the DD alone...???

Just a hedzup, kids... That was *not* me who deleted the thread--and this is the first post on this one I see mentioning the stock...

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Nashoba Holba Chepulechi
Adventures in microcapitalism...

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Egg Inspector
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what happened. I went to pick up my daughter, opened up the comp. hit the thread (which was minimized, and it said

"sorry, you have requested a thread that doesn't exist!"

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Purl Gurl
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I did it.

All you have to do is display common courtesy.

Agree, disagree, argue, fight, love each other,
hate each other, but leave out the personal insults.

This is Allstocks. This is not the place for
personal insults. Those belong over at Raging Bull.

Purl Gurl

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Egg Inspector
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actually:

copied/pasted-

FYI
You have requested a topic that does not exist!

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10of13
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OK..well here's some of the stuff..

Peaser01
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posted June 06, 2006 10:06 AM
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The granting of the orphan drug status is designed to encourage the development of drugs which are necessary but would be prohibitively expensive/un-profitable to develop under normal circumstances.

In the United States, an orphan drug is any drug developed under the Orphan Drug Act of 1983, a federal law concerning rare diseases ("orphan diseases"), defined as diseases affecting fewer than 200,000 people in the United States or low prevalence is taken as prevalence of less than 5 per 10,000 in the community . This has been adopted as a subclause of the Food and Drug Administration (FDA) regulations. Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions and a monopoly on that drug for an extended time (twenty years). Under the act many drugs have been developed, including drugs to treat HIV/AIDS, cystic fibrosis, and snake venom.

A similar status exists in the European Union, administered by the Committee on Orphan Medicinal Products of the European Medicines Agency.

Source: http://en.wikipedia.org/wiki/Orphan_drug

Peaser01
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posted June 17, 2006 02:53 PM
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A nice read on how Xechem came to being:

Survival Medicine
by Mukul Pandya
In an industry riddled with casualties, Ramesh Pandey is a survivor


Ramesh S. Pandey, chief executive officer of Xechem, a biotechnology company in New Brunswick, N.J., has an office where these days an unnatural state of disorder prevails. On a Monday in late November, his desk was piled with scientific and business documents, some of which lay in small heaps on the floor. Product bottles competed for space with company literature on tables and window sills. Pandey, a soft-spoken but energetic man, grinned as he apologized for the mess. "My office has never been like this," he said, "But every other day I have been running around."

Pandey has had good reasons to run around, because in some ways, his office symbolizes Xechem's problems. Though the company seemed to be headed for success when Pandey spun it off six years ago from LyphoMed, a generic drug company in Chicago, during the past year it has fallen upon hard times. Xechem's difficulties are typical of the double whammy that confronts most start-up biotech firms -- high R&D costs combined with low or non-existent revenues. At one point last year, Xechem was burning cash at the rate of more than $200,000 a month. As the company's accumulated losses exceeded $18 million in December 1995, some observers wondered whether the company would survive.

It will -- at least for now -- because Pandey's energetic running around has paid off. On Nov 19, Xechem announced that a group controlled by David Blech, a well-known but controversial investor in the biotechnology industry, will invest $5.5 million in the company over the next nine months. As a result of the deal, Blech and his associates will replace Pandey as Xechem's controlling shareholders, with a stake of more than 70 percent. Pandey, however, will remain the CEO as well as the second-largest shareholder. He is delighted at the deal because the capital infusion will allow Xechem to develop products that he believes could become big winners in the future. "With Blech's investment and expertise, our future is very bright," he says. "In the next three to five years, we could have sales of $30 million to $50 million."

Pandey's optimism is based largely on a plant-based product called paclitaxel, a drug used in the treatment of ovarian and breast cancer. Xechem cannot sell paclitaxel until December 1997, because Bristol-Myers Squibb, the New York City-based pharmaceutical giant, has exclusive rights to its sale. After that, however, Pandey believes that Xechem's version of paclitaxel --which Bristol-Myers Squibb sells under the brand name Taxol -- could command a large market. Pandey says initial tests have been encouraging, and now that Xechem has the capital, it will be able to move the product along the Federal Drug Administration's approval process.

Xechem also has other irons in the fire. Through a subsidiary called Xetapharm, Pandey wants to introduce natural products from India and China in the United States. The company has agreements with the International Institute of Ayurveda in Coimbatore and with Beijing Medical University. "We have some work going on at the International Institute of Ayurveda to make plant extracts," he says. "Though quality control on ayurvedic herbal medicines is a big problem, there is a great need for these products."


If Pandey has been able to roll with the punches in the volatile field of biotechnology, the reason is that he has been in the pharmaceutical industry for a long time. A native of the Rani Khet region of Nainital in Uttar Pradesh, Pandey completed his Ph.D. at the National Chemical Laboratory in Pune before coming to the United States in 1967. After doing three years of post-doctoral research at the University of Chicago in Urbana, Pandey went to India briefly but then returned to the United States in 1972.

His expertise was in antibiotics and anti-cancer drugs development, and he joined the National Cancer Institute in Frederick, Md., which was doing research in these fields. By the late 1970s, however, he was tired of government bureaucracy. He was eager to get into business, possibly with other Indians who were as frustrated as he.

"I met a lot of people, but these damn people would say, 'Write a business plan, do this, or do that,'" he says. "The business world sees things differently than scientists."

Pandey's break came in 1982, when he met John Kapoor, an Indian businessman who ran LyphoMed in Chicago. LyphoMed sought out drugs that had gone or were about to go off patent and made generic versions of these products. The two men had dinner together, and Pandey told him about his desire to get into business. LyphoMed was going public at the time, and Kapoor was busy, but he told Pandey to keep in touch.

In 1983, Pandey joined Abbott Laboratories, but just nine months later, he got a call from Kapoor. LyphoMed, Kapoor said, was keen to develop a generic version of vancomycin, an anti-bacterial drug. Though Pandey had never produced the drug before, he told Kapoor that he was confident he could do it. He added, though, that the investment might be as high as $8 million to $10 million. Kapoor agreed, so Pandey resigned from Abbott. Pandey, Kapoor and John Curry, an American investor, in 1984 formed Xechem as a joint venture.

Raising $10 million to set up a vancomycin plant, however, proved to be daunting. A major hurdle to getting the funding was Pandey's lack of experience in developing the product. "When I asked LyphoMed to build the facility, the company said, 'What if you can't do it, all our money will go down,'" Pandey says.

As an alternative, LyphoMed promised to support Pandey while he researched the product. Pandey then approached Rutgers University's Waksman Institute of Microbiology, which was interested in the project. The institute named him a visiting professor, and Pandey used its facilities and researchers to direct a LyphoMed-funded project. On March 17, 1987, LyphoMed received FDA approval for vancomycin. "Once we got the approval, the money we spent on developing the product was recovered in two weeks," says Pandey.

Armed with this success, Pandey asked LyphoMed again to build the vancomycin plant. This time, he was told it would take too long -- it would be better to farm out the job out to a company that had the infrastructure. Pandey agreed, so in 1987 LyphoMed began to produce vancomycin with help from Denmark's Dumex and Japan's Fujisawa. The same year, Pandey renegotiated his deal with LyphoMed, which was doing very well. Xechem became a fully-owned subsidiary of LyphoMed. Pandey's salary shot up, and he also received options in LyphoMed stock.


Life changed for Pandey in 1990 when Kapoor and his associates decided to sell LyphoMed to Fujisawa in a $1 billion deal. "Kapoor, who owned about 25 percent of LyphoMed, made millions of dollars, as did many other people," recalls Pandey. "I also made some money because I owned LyphoMed stock." The biggest change, however, was that Fujisawa was not interested in Xechem, so Pandey bought the company for $125,000. After initially considering keeping Xechem in Chicago, Pandey decided to move the company to New Jersey.

New Jersey attracted Pandey for two reasons. As the state that has the headquarters of companies like Merck, Johnson & Johnson and American Home Products, among others, he considered it the "pharmaceutical capital of the world." More importantly, however, his stint at Rutgers had showed him that being near a university can offer invaluable support systems -- libraries, laboratories, research assistants -- to a fledgling start-up biotech firm. So Pandey set up shop in a 10,000 sq. ft. facility in New Brunswick near Rutgers. The company continued to work on anti-cancer drugs, with support from Small Business Innovation Research grants from the National Aeronautics and Space Administration and the National Cancer Institute.

Young biotech companies are voracious consumers of capital, and Xechem was no exception. Since the company's products had not received FDA approvals, it had no sales revenues and soon the grant money ran out. Xechem was then approached by a group of California investors who were interested in paclitaxel's potential, and who put Pandey in touch with Kensington West, a New York City investment bank. Xechem went public in April 1994, raising $4.5 million. This capital infusion allowed Pandey to hire more people and expand Xechem's facilities to 25,000 sq. ft. The company's stock also rose from $5 to $13. Forbes magazine listed Xechem as one of the best new issues, and the company was profiled on CBS.

Unfortunately for Pandey and Xechem, problems cropped up. First, an agreement that Xechem had struck with a marketing firm in Canada unraveled because of disagreements over cost-sharing, and the stock took a hit on Wall Street. It now trades for less than $1. Another key problem was that some of the scientists from big companies whom Pandey had hired were unable to adjust to a small-company environment. Getting drug approvals also proved to be a more time consuming and complex process than Pandey had expected. As cash got tighter, Pandey had to lay off people. Xechem once had 34 employees, of whom 18 had Ph.Ds Today the company is down to 24 people.

Pandey now wants to move Xechem forward again with Blech's capital. One of his main priorities will be to rebuild the company's scientific staff. "We will refocus the company," he says. "Until now, we have done only technology development. We will focus on abbreviated new drug applications for drugs going off patent. The company will start making money in one and a half or two years."

Pandey says he has learned several lessons from his experience. "Our ambitions were very high, and certain things did not work out," he says. "If I had to think again, maybe I would have done things slightly differently. People don't want to touch this business with a thousand-foot pole because it is a high-risk business. It is very important to have the necessary financing right from the beginning. You can't just trust people who say, 'Don't worry, we'll get you the financing.' In December, we hardly had any money. I now understand how companies get into trouble. It doesn't have to be millions; companies can get into trouble for a very small amount of money."

While Xechem is not yet successful, it is undoubtedly a survivor. "People told me six months ago that I should close my shop, because I could not survive," says Pandey. "But the bottom line is, I survived. I have an investor who believes in my company and my products. That's the big thing. People have many ideas. But do they have the guts to make them happen? That is what makes the difference."

http://www.littleindia.com/archive/dec96/survive.htm

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#1 Rule: Protect your capital! #2 Rule: Never fall for the BS on the boards!

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Egg Inspector
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well, here's my last post. I didn't even get to see if there were any replies to it, any 'that's ridiculous Egg' comments. it's all on the **LOST THREAD**

I'll re-post it, to hear any reaction, spell checked and finished off this time.

[Smile]

quote:
Originally posted by The Phat Man:
is this what you're referring to?


By: alexng00
07 Jul 2006, 07:18 AM EDT
Msg. 72460 of 72499
Jump to msg. #
Gm all,
here is below the email I received from my contact today :

"Sorry my connection has been down and its so frustrating. I had to go to a cybercafe to send this mail. Yesterday the president arrived at about 12noon with his entourage. Nafdac Bos was not present as of the time I left. but was represented by one of her directors. Also ther were the ministers of Health, Information and Science and Technology. A lot of staff from the ministry of Science and Tech were there since the were handling the project. I also saw over 30 whites there, ofcourse I did not know any of them Except for Pandy who was sitting proudly at the high table. The Drugs were only displayed at the table so I did not have a clear look at it. The media was also there. NTA, DBN, AIT and I think 2 national radio station. The were about 400 people ofcourse I did not count them. It was also rainy so when the President was coming those of us that were not invited were virtually pushed out so I had to leave. I also asked whether the drugs are out for sale but they said that The logistics of sales will commence after the launch.
I hope this small info is useful.
Once again sorry for the delay in report. I also noticed you called last nite. I had slept off by then . hope to hear from you soon"

I call him this morning and we got a great discussion, this guy is in the deep knowledge of the system in Nigeria. He says that the launch was huge and so important that the President, dignitaries, may guests, TV, Radio, Newspaper are there, there are 1 or 2 events like that per year in Nigeria. He says that most people in Nigeria can afford the drug, even the poor people can afford this because their family and friends will help, that the mentality there. I told him that Steve says that the governement will buy the drug for their employees, he says in that case it's huge and it's a good guaranty for this drug, he also says that there are many organisations and foundations who can buy this drug and help the people. I think you need to realize the importance of the sickle cell disease and what is it's meaning. He explains to me that the people suffering from this disease are horrible, alot of pain and die, he says you should see a patient suffering the disease and then you can really realize that, it's bad really bad. He says this drug is very important to these patients so most of them need that.
I told him about the price per month between 12-20 dollars, he says it's not expensive and they can afford that. With that whole picture I can see the revenues will be huge for the companies, as it is sold in Nigeria first and then exported to other African countries, he says that he knows many African countries need this drug for their patients of sickle cell disease.
Now it's time for the company to execute and what I can undersatnd the potential revenue is huge, I think we have a gold mine here, let them time to do it, Roma is not build in one day. Btw I invite everybody to search on Internet about the articles for the launch details, it should be available at any time now. glta

----------------------------------------------------------
when trying to determine credibility or not, for the above post, for me it is important to pick up on small clues of language usage. I have clients around the globe, and friends in Europe, S.Africa, Asia, Australia, Russia, Ukraine, it goes on and on. I am no Language expert, but I like to think I can hear similarities in language usage, and pick-up on accents, and tendencies well.

so the following in one Eggs Opinion. Hope you enjoy. [Smile]

Here are a few examples of that usage i.e.

Now it's time for the company to*execute and *[from]what I can undersatnd the potential revenue is huge,
*"execute" this is someone not very comfortable with the English language, trying to show a higher level of verbal intelligence. use of this word IMO shows this not to be a scam. a scam would say: 'go to work'/'start producing medicine' etc..
"from" also, note the missing 'from'. classic broken English, hard to impersonate.

I think we have a gold mine here,

*let them time to do it, *Roma is not build in one day.
"let" them time... perfect misuse. it is obviously 'give' them time.

"Roma is not build in one day" this was the absolute clincher for me. first of all:

'Roma'. Rome is only referred to as Roma outside the English speaking world, and outside the English speaking world it is ONLY referred to as 'Roma', never Rome.
"is not built in one day" come on? do I need to elaborate. 'Rome was not built in a day', an impostor letter (scam) would almost certainly not get this, this subtly, wrong IMHO

Btw I invite everybody to search on Internet about the articles for the launch details, it should be available at any time now
---------------------------------------------------------

so there's one Eggs opnion of a few examples of use, or misuse of language that gives people away.

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Purl Gurl
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I disagree with majority opinion.

"glta"

The email is a fabrication.

Purl Gurl

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bond006
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Alex is Swiss and he has been posting for a long time in Penny Pickers in there trusted members only secection.. English is nat a first language to him. He has had some good info in the past and I personaly feel that he is not trying to mislead anybody
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worthashot
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I replied to it egg. I replied that it was one heck of a coincidence that it is the same "Alex" that miraculously found that Nigerian article (the one that started this entire XKEM run) from 6/18/06 by mispelling "Nicosam" in his websearch (see ihub and pennnypickers posts form june 21st to confirm). I have real problems with him being fed info to share to us and lying about the sources. I am not a basher, but I am getting more skepticle every day about XKEM.
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Dustoff 1
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The editorial by Phat man was a good read..
Should be re-posted.

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Egg Inspector
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quote:
Originally posted by amswap:
10, if you click on some of the names of people who posted in that thread and click on recent posts, it was comeing up that way. Not sure it still is.

And sorry about above. I know she isn't capable of answering a question. Not sure why I bothered asking.

Ams...I tried this too, it doesn't even come up on the recent posts, not mine, not 10's, not yours...

it's gone [Frown]

Posts: 1307 | From: Pittsburgh, PA | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
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ROTFLMAO [Smile]

I can't believe what I am reading about what kind of behavior being tolerated!

I don't need to elaborate, do I??

Posts: 1307 | From: Pittsburgh, PA | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
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purl Gurl, which email is fabrication?
If you are refering to the post of Alex' friend in Nigeria, it is not a fabrication from what I've seen. Everything this person has said through Alex has proven to be true.

--------------------
corn oil comes from corn, olive oil from olives, where does baby oil come from?

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quote:
Originally posted by worthashot:
I replied to it egg. I replied that it was one heck of a coincidence that it is the same "Alex" that miraculously found that Nigerian article (the one that started this entire XKEM run) from 6/18/06 by mispelling "Nicosam" in his websearch (see ihub and pennnypickers posts form june 21st to confirm). I have real problems with him being fed info to share to us and lying about the sources. I am not a basher, but I am getting more skepticle every day about XKEM.

I remember that mispelling [Smile]
Posts: 1307 | From: Pittsburgh, PA | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
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