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This is a play I still think could pop more.
The CEO is my dads neighbor at one of his properties. He is in at 2.02 and told me about this months ago. GRRR.
TTP - TITAN PHARMA INC (AMEX)
Date Open High Low Last Change Volume % Change 12/07/06 3.00 4.10 3.00 3.65 +1.28 7364800 +54.01%
Composite Indicator Trend Spotter TM Buy
Short Term Indicators 7 Day Average Directional Indicator Buy 10 - 8 Day Moving Average Hilo Channel Buy 20 Day Moving Average vs Price Buy 20 - 50 Day MACD Oscillator Sell 20 Day Bollinger Bands Buy
Short Term Indicators Average: 60% - Buy 20-Day Average Volume - 670250
Medium Term Indicators 40 Day Commodity Channel Index Buy 50 Day Moving Average vs Price Buy 20 - 100 Day MACD Oscillator Buy 50 Day Parabolic Time/Price Buy
Medium Term Indicators Average: 100% - Buy 50-Day Average Volume - 338134
Long Term Indicators 60 Day Commodity Channel Index Buy 100 Day Moving Average vs Price Buy 50 - 100 Day MACD Oscillator Buy
Long Term Indicators Average: 100% - Buy 100-Day Average Volume - 226306
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Titan Reports Positive Results in Iloperidone Phase III Clinical Trial Thursday December 7, 1:46 pm ET
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Titan Pharmaceuticals, Inc. (AMEX:TTP - News) today announced positive results from a Phase III clinical trial evaluating iloperidone, an atypical antipsychotic, in patients with schizophrenia. In this important study, iloperidone demonstrated statistically significant improvement compared to placebo on the Positive and Negative Symptom Scale (PANSS), the trial's primary endpoint. Iloperidone also achieved significant efficacy on the positive and negative symptom subscales of PANSS. The safety profile was consistent with what has been observed in previous iloperidone Phase III trials. ADVERTISEMENT
Iloperidone's efficacy and safety was also evaluated in this study in patients with specific genetic profiles using pharmacogenetics (PG), in order to potentially give physicians and patients information to help individualize their antipsychotic therapy. It had been previously identified that a certain polymorphism in a gene, occurring in approximately 70% of patients, may be associated with the pathogenesis of schizophrenia and appeared to correlate with iloperidone response. Iloperidone achieved statistical significance vs. placebo on the PANSS scale in these patients, with a magnitude of response greater than that seen in the overall iloperidone population.
The Phase III trial was a randomized, double-blind, placebo-controlled, multi-center, 4 week study that enrolled 604 patients with schizophrenia. The trial evaluated 12 mg of iloperidone dosed twice-daily, or 24 mg per day. The primary endpoint was efficacy vs. placebo in PANSS (total) using the Mixed Method Repeated Measures (MMRM) methodology. The secondary endpoint was efficacy in the previous described genetic subpopulation.
The efficacy results vs. placebo include:
* Efficacy (intent to treat population):
* PANSS (total): p=0.006
* PANSS (positive symptoms only): p=0.0009
* PANSS (negative symptoms only): p=0.027
* Brief Psychiatric Rating Scale (BPRS): p=0.0128
* Efficacy (genetic subpopulation):
* PANSS (total): p=0.002
Using Last Observation Carried Forward (LOCF) methodology, iloperidone achieved statistical significance in both the primary and secondary endpoints. Iloperidone efficacy was also equal to the active control arm.
The study also evaluated the effect of iloperidone on the QT interval, a well understood atypical antipsychotic class side effect. The mean QT prolongation was consistent with previous experience. No patients experienced QT intervals in excess of 500 milliseconds, a threshold of concern to the FDA. The study also confirmed, with an additional genetic marker, that the QT prolongation was shorter in the majority of patients who are good iloperidone metabolizers.
The specific results include:
* QTc change from baseline:
* All patients: 11.4 milliseconds (msec)
* Good metabolizers: 10.4 msec
* Poor metabolizers: 15.0 msec (p=0.008, good vs. poor)
"We are very pleased with these results for iloperidone in this Phase III study", stated Louis R. Bucalo, Chairman, President and CEO of Titan Pharmaceuticals. "These results strongly support our position in the advancement of iloperidone".
The Phase III study was performed by Vanda Pharmaceuticals Inc. (Nasdaq: VNDA - News). Vanda acquired the rights to iloperidone from Titan's sublicensee, Novartis. Vanda plans to file an NDA for iloperidone by the end of 2007. Titan's agreements provide that Titan will receive a royalty of between 8-10% on worldwide sales of iloperidone.
About Schizophrenia
Schizophrenia is a chronic, debilitating mental disorder characterized by hallucinations, delusions, racing thoughts and other psychotic symptoms (collectively referred to as "positive symptoms"), as well as moodiness, anhedonia (inability to feel pleasure), loss of interest, eating and sleep disturbances, and difficulty concentrating (collectively referred to as "negative symptoms"). Schizophrenia develops in late adolescence or early adulthood in approximately 1% of the world's population. Genetic and environmental factors are believed to be responsible for the disease.
About Titan Pharmaceuticals
Titan Pharmaceuticals, Inc. (AMEX:TTP - News) is a biopharmaceutical company focused on the development and commercialization of novel treatments for central nervous system disorders, cardiovascular disease, bone disease and other disorders. Titan's products in development utilize novel technologies that have the potential to significantly improve the treatment of these diseases. Titan also establishes partnerships with government institutions and other leading pharmaceutical development companies. For more information, please visit the Company's website at www.titanpharm.com.
The press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to the Company's development program and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to difficulties or delays in development, testing, regulatory approval, production and marketing of the Company's drug candidates, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug candidates that could slow or prevent product development or commercialization, the uncertainty of patent protection for the Company's intellectual property or trade secrets and the Company's ability to obtain additional financing if necessary. Such statements are based on management's current expectations, but actual results may differ materially due to various factors, including those risks and uncertainties mentioned or referred to in this press release.
Contact: Titan Pharmaceuticals, Inc. Robert Farrell Executive Vice President & CFO 650-244-4990 or Media/Investors: The Trout Group Ian Clements, 415-392-3385
-------------------------------------------------------------------------------- Source: Titan Pharmaceuticals, Inc.
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Titan drug does well in Phase III trial Thursday December 7, 4:41 pm ET
Titan Pharmaceuticals Inc. said its antipsychotic drug Iloperidone did well in a Phase III trial in patients with schizophrenia. The South San Francisco drug company (AMEX: TTP - News), which has about 50 workers, said Thursday that Iloperidone showed statistically significant improvement compared with a placebo.
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The trial used 604 patients. Rockville, Md.-based Vanda Pharmaceuticals Inc. (NASDAQ: VNDA - News) ran the Phase III trial. Vanda licensed the rights to Iloperidone from Titan, which licensed them from Swiss giant Novartis AG.
Vanda plans to apply by the end of next year with U.S. regulators to sell the drug. If it's approved, Titan will ultimately get royalties of between 8 percent and 10 percent on sales of the drug.
Published December 7, 2006 by San Francisco Business Times
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View: Annual Data | Quarterly Data All numbers in thousands PERIOD ENDING 30-Sep-06 30-Jun-06 31-Mar-06 31-Dec-05 Total Revenue 1 1 1 61 Cost of Revenue - - - -
Gross Profit 1 1 1 61
Operating Expenses Research Development 3,264 2,378 3,687 3,047 Selling General and Administrative 1,287 1,237 1,133 1,231 Non Recurring - - - - Others - - - -
Total Operating Expenses - - - -
Operating Income or Loss (4,550) (3,614) (4,819) (4,217)
Income from Continuing Operations Total Other Income/Expenses Net 210 188 114 170 Earnings Before Interest And Taxes (4,340) (3,426) (4,705) (4,047) Interest Expense - - - - Income Before Tax (4,340) (3,426) (4,705) (4,047) Income Tax Expense - - - - Minority Interest - - - -
Net Income From Continuing Ops (4,340) (3,426) (4,705) (4,047)
Vanda Pharma Schizophrenia Drug Effective Thursday December 7, 3:35 pm ET Vanda Pharma Late-Stage Trial Shows Schizophrenia Drug Effective; Shares Set 52-Week High
ROCKVILLE, Md. (AP) -- Shares of Vanda Pharmaceuticals Inc. hit a new 52-week high Thursday after the biotech drug developer said its schizophrenia treatment, iloperidone, was effective in a late-stage clinical trial, putting the company closer to filing a new drug application with the Food and Drug Administration in late 2007. ADVERTISEMENT
Shares of Vanda jumped $10.70, or 69 percent, to $26.20 in afternoon trading on the Nasdaq on more than 30 times their average volume. Shares, which reached a new year-high of $28.67 earlier in the session, previously traded between $7.21 and $17 over the past 52 weeks.
Vanda acquired rights to the drug from Novartis AG, who licensed it from Titan Pharmaceuticals Inc. Shares of South San Francisco, Calif.-based Titan surged $1.31, or 55.3 percent, to $3.68 on the American Stock Exchange on 35 times their average volume.
The compound is an atypical antipsychotic, and was tested in a four-week trial with 604 patients with schizophrenia, a chronic, debilitating mental disorder.
According to the data, patients taking iloperidone demonstrated statistically significant improvement versus those taking a placebo on the Positive and Negative Symptom Scale (PANSS), the trial's primary endpoint. Positive symptoms of schizophrenia include hallucinations, delusions, racing thoughts and other psychotic symptoms, while negative symptoms include moodiness, anhedonia (inability to feel pleasure), loss of interest, eating and sleep disturbances, and difficulty concentrating.
The company said iloperidone also was significantly effective on the positive and negative symptom subscales of PANSS.
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