posted
i know this is a little technical (OK verytechnical). it's not my feild of expertise,and i do not pretend to have full understand ing of this stuff, but i am exposed to it on a regular basis.
Endocytosis is an important way for cells to take up liquids and particles from their environment. It requires membrane bending to be coupled with membrane fission, and the actin cytoskeleton has an active role in membrane remodelling. Here, we review recent research into the function of Bin–Amphiphysin–Rvs (BAR) domain proteins, which can sense membrane curvature and recruit actin to membranes. BAR proteins interact with the endocytic and cytoskeletal machinery, including the GTPase dynamin (which mediates vesicle fission), N-WASP (an Arp2/3 complex regulator) and synaptojanin (a phosphoinositide phosphatase). We describe three classes of BAR domains, BAR, N-BAR and F-BAR, providing examples of each discussing and how they function in linking membranes to the actin cytoskeleton in endocytosis.
BAR proteins are something important to pay attention to
in laymans terms? we are on the verge of being able to enter cells chemically and add or subtract their basic abilities.
alot of money still has to go into this. i am not telling you to run out dump your investments into the co's doing this. i've already seen "cash burn" take most of my investments in them.
but the state of the art today is such that we have collected a very large part of the intel we need to be able to alter basic single cell organisms into micro factories. (don't get too worried about the dangers, this is how we make wine and beer already)
soon, we will be seeing industrial applications (for better or worse). this i sthe next industrial revolution and it will make the computer revolution look lame.
and yes, the DOE is one the main driving forces behind the data collection. it's been along time coming, and i can't say when it will happen, but we get closr every day.
they have IDed specific proteins that cause tubes to open up in a cell that allow large molecules to enter and exit. the next step is to apply it to algae (for instance) to increase it's ability to produce and than release lipids (oils that can be made into fuel)
this could eliminate harvesting altogether since the oils could be released freely. harvesting the oil from the algae is the most expensive process because you have to break the cells and chemically treat them to get the oils out...
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(OK verytechnical). it's not my feild of expertise,and i do not pretend to have full understand ing of this stuff, but i am exposed to it on a regular basis. 
